The festival of cards shown in Real Madrid's 2-0 home defeat to Barcelona will have ramifications far beyond Wednesday night, with both sides now lacking several players for the return-leg at Camp Nou next Tuesday.
The first leg at the Bernabeu saw Sergio Ramos pick up a suspension after earning a yellow card, while Pepe's straight red will see him sit out the return leg.
Almost certainly set to miss out is Real Madrid coach Jose Mourinho, who was sent to the stands for what he described as some laughter and clapping towards referee Wolfgang Stark in the aftermath of Pepe's dismissal.
On the other side, Barcelona's substitute goalkeeper Jose Manuel Pinto was the first to see red, the veteran receiving his marching orders for his part in a half-time melee.
Andres Iniesta is likely to make a comeback for Barcelona, while Ricardo Carvalho returns from suspension for Real Madrid.
It leaves the list of missing names for the second-leg clash longer than it already was. Players in italics could potentially return for the match: